Fig. 1

Altered signaling proteins in models of SCA3. a Signaling proteins responding to expanded ataxin-3 expression in the indicated SCA3 models (HEK^148Q, MEF^148Q and brain of SCA3 mouse model) in comparison to the respective controls (HEK^wt, MEF^wt, and control brain). In all three different SCA3 disease models, we observed a significant overlap of dysregulated signaling proteins. For clarity, only the proteins displaying alterations of more that ± 20% relative to the corresponding control levels are shown. b A fragment of the signaling network illustrating connections between shared proteins in a