Fig. 7

The illustration shows the different anatomical and neurochemical condition in the different subregions of the hippocampal DG and CA3 in sham and SNI mice. In the DG of SNI mice there is an increase in glutamate (Glu) and a reduction in GABA levels in the molecular layer (MOL), granular cell layer (GCL), and hilus (Hil) of the DG. In the SNI mice an increase in levels of histamine and a reduction in those of dopamine and norepinephrine are observed in the CA3, where the projections of catecholaminergic and histaminergic neurons arrive from the LC. The glutamatergic pyramidal neuron, the glutamatergic projection fiber from the entorhinal cortex (EC, lateral perforating path, LPP) and the extracellular glutamate are painted in red, the GABAergic interneurons and the extracellular GABA in green, the histaminergic (HA), noradrenergic (NE) and dopaminergic (DA) projection neurons are painted in pink, purple and dark green, respectively. A representation of the organization of the different hippocampal subregions is shown in the left panel