Fig. 2
From: A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels
Functional effect of the P2455H mutation on Cav2.1 inactivation. a Steady-state inactivation curves for CaV2.1α1 + 47/β4/α2δ-1 or P2455H + 47/β4/α2δ-1 channels. Inset: overlap of the activation and inactivation curves to illustrate the size and position of the window current. b Mean voltage for half inactivation for CaV2.1α1 + 47/β4/α2δ-1 or P2455H + 47/β4/α2δ-1 channels (**p = 0.0073, vs CaV2.1α1 + 47/β4/α2δ-1, two-tailed Student’s t test). c Fraction of current remaining at the end of a 240 ms depolarizing pulse using Ca2+ or Ba2+ as a charge carrier (*p < 0.05 and **p = 0.0076, two-tailed Student’s t test). d Comparison of the time course of recovery from inactivation for CaV2.1α1 + 47/β4/α2δ-1 and P2455H + 47/β4/α2δ-1 channels. Data are represented as mean ± SEM. Numbers in parentheses represent the number of cells recordings per variant