Fig. 2

The anxiety- and depression-like behavior in CPMS mice were recovered by anti-depressant treatment. a 7-week-old mice were treated with venlafaxine or saline for 3 weeks until they were 9 weeks of age before the behavior test. b The anxiety level of each group was measured using duration time in closed arms in elevated plus maze (EPM) (CTL-saline (n = 9); 77.67 ± 3.399, CTL-venlafaxine (n = 7); 73.71 ± 5.366, CPMS-saline (n = 10); 91.40 ± 1.500, CPMS-venlafaxine (n = 10); 77.00 ± 3.370). c The immobility time of mice in the forced swim test (FST) was determined to measure despair (CTL-saline; 175.8 ± 16.33, CTL-venlafaxine; 141.4 ± 23.46, CPMS-saline; 239.2 ± 13.48, CPMS-venlafaxine; 173.0 ± 10.36). d Ratio of sucrose consumption in the sucrose preference test (SPT) was determined to measure anhedonia (CTL-saline; 95.89 ± 0.5386, CTL-Venlafaxine; 91.57 ± 3.146, CPMS-saline; 83.60 ± 3.603, CPMS-Venlafaxine; 94.88 ± 0.6105). All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, vs. CTL-saline, ^&&p < 0.01, ^&&&p < 0.001 vs CTL-venlafaxine, ^#p < 0.05 vs CPMS-venlafaxine