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Fig. 7 | Molecular Brain

Fig. 7

From: Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice

Fig. 7

Summary picture. Cumulative mild stress during brain development (from fetus to adolescence) induced long-lasting depressive symptoms in young adulthood. Naïve T cell was differentiated to Th17 cells under the increase of differentiation factors such as IL-6 and TGF-β with the hyperactive form of STAT3. According to the increase of Th17 cell population, the high level of IL-17 was produced and promoted the activation of microglia. As a result, the abnormal inflammatory response induced by IL-17 affects more long-lasting anxiety- and depression-like behavior in young adulthood

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