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Fig. 2 | Molecular Brain

Fig. 2

From: A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability

Fig. 2

Body weight, survival curve and seizure susceptibility analysis of GluA2+/ECS(G) mice. a GluA2+/ECS(G) mice exhibit reduced body weight, as compared to WT littermates at 8 weeks of age (n = 6 GluA2 GluA2+/ECS(G) mice, 11 WT; unpaired t-test). b GluA2+/ECS(G) mice exhibit premature death and an approximate median survival age of 9 weeks (n = 42 WT, 170 GluA2+/ECS(G) mice; Kaplan-Meier survival analysis). c GluA2+/ECS(G) mice exhibit increased seizures following low-dose (10 mg/kg) of intraperitoneal KA injection that is blocked by the Ca2+-permeable AMPAR antagonist, IEM-1460 though not by AP5 (n = 16 (WT), 17 (GluA2+/ECS(G)), 7 (WT + IEM-1460), 11 (GluA2+/ECS(G) + IEM-1460), 3 (WT + AP5), 11 (GluA2+/ECS(G) + AP5); Repeated measures ANOVA). Data in (a) represent mean ± SD and in (c) represent mean ± SEM. * = compared to WT, # = compared with GluA2+/ECS(G), ^ = compared with WT + IEM-1460, ■ = compared with WT + AP5. One symbol, p < 0.05, two symbols, p < 0.01, three symbols, p < 0.001, four symbols, p < 0.0001

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