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Table 1 List of differentially expressed miRNAs detected by miRNA microArray

From: A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling

miRBase accessionmiRNA nameNMDABicuculline
fold changep adj.fold changep adj.
MI0004654mmu-miR-6895.240.070.911.00
MIMAT0004893mmu-miR-574-5p2.380.101.021.00
MIMAT0005837mmu-miR-11872.210.091.031.00
MIMAT0003469mmu-miR-6902.120.101.001.00
MIMAT0003499mmu-miR-7091.990.230.901.00
MIMAT0007867mmu-miR-18951.870.150.991.00
MIMAT0005846mmu-miR-467f1.790.140.981.00
MIMAT0003731mmu-miR-671-5p1.730.100.971.00
MIMAT0005834mmu-miR-466i-3p1.500.100.991.00
MIMAT0003182mmu-miR-494-3p1.350.151.001.00
MIMAT0003505mmu-miR-7141.340.221.011.00
MIMAT0007864mmu-miR-1897-5p1.300.361.011.00
MIMAT0007874mmu-miR-19041.300.211.021.00
MIMAT0004882mmu-miR-466f-3p1.280.180.971.00
MIMAT0007878mmu-miR-1894-3p1.280.221.001.00
MIMAT0003495mmu-miR-7051.280.151.021.00
MIMAT0005839mmu-miR-669f-3p1.220.150.991.00
MIMAT0003502mmu-miR-712-5p1.220.151.021.00
MIMAT0004883mmu-miR-466 g1.210.230.991.00
MIMAT0017053mmu-miR-2121.020.951.860.72
MIMAT0016984mmu-miR-1321.060.851.381.00
  1. Differential expression of miRNAs after activation of extrasynaptic vs. synaptic signaling. miRNA microarray data for the most strongly regulated miRNAs are shown. Extrasynaptic signaling was induced by bath application of NMDA (20 μM). Synaptic signaling was induced by application of the GABA-A receptor antagonist, bicuculline (50 μM) to reduce tonic network inhibition and thereby increase global synaptic activity. Fold-changes compared to untreated cells were calculated from three independent experiments. P-values were determined by two-tailed t test and adjusted with Benjamini-Hochberg correction for multiple testing
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