Fig. 5
From: Core transcriptional regulatory circuits in prion diseases
Core transcriptional regulatory circuits (TRCs) in microglia and OPCs and characteristics of TRCs. A-B) TRCs in microglia (A) and OPCs (B). Node shapes represent TFs (diamonds) and target genes (circles), and large diamonds denote DETFs. Node colors represent EU (orange), LU (magenta), and DN (green) genes. Edge types indicate activation (arrow), inhibition, and unspecified interactions (blunted arrow). C-D) Relationships among EU (top Venn diagram) and LU (down Venn diagram) target genes regulated by EU or LU TFs in microglial (C) and OPC (D) TRCs. Label colors indicate EU (orange) and LU (magenta) genes. E-F) Comparison of integrated log2-fold-changes of LU target genes regulated by EU and LU TFs in microglial (E) and OPC (F) TRCs. P-value was computed by two-tailed Student t-test. G-H) Heat map showing the numbers of target genes included in microglial (G) and OPC (H) TRCs. Numbers of target genes involved in prion disease-associated GOBP were counted and displayed in the heat map