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Fig. 1 | Molecular Brain

Fig. 1

From: Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors

Fig. 1

Enhanced anxiety in neuropathic pain rats following mCCD. a, Representative traces show the movement of sham and mCCD rats in elevated plus maze for 5 mins, mCCD rats (n = 13) spent less time in the open arms of elevated plus maze and showed a decrease in open arm entries compared with sham rats (n = 13). b, Representative traces show the movement of sham and mCCD rats in the open field test over a period of 15 min, mCCD rats (n = 13) spent significantly less time in the central zone in the open field test compared with sham rats (n = 13). Total distance travelled in the open field test was not changed compared with sham rats. c, The time course of ipsilateral and contralateral hind paw mechanical withdrawal thresholds after mCCD (sham group: n = 11, mCCD group: n = 8). The ipsilateral and contralateral hind paw withdrawal thresholds were significantly decreased below baseline on the 1st postoperative day and reached their lowest peak during the 7th to 14th postoperative day. d, Motor performances on the accelerating rotarod of mCCD rats (mCCD: n = 7, sham: n = 7). *p < 0.05, **p < 0.01 compared with that of sham group

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