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Fig. 5 | Molecular Brain

Fig. 5

From: Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors

Fig. 5

Upregulation of BKCa β4 subunit protein and mRNA in the ACC during neuropathic pain associated anxiety-like behavior. a, The schematic diagram of the behavioral and biochemical experiments. b, Quantification of the mRNA levels of BKCa channel subunits in the ACC between mCCD (n = 7) and sham (n = 6) rats on postoperative day 7. c, Quantification of the mRNA levels of BKCa channels in the insular cortex between mCCD (n = 7) and sham (n = 6) rats on postoperative day 7. d, Quantification of the mRNA levels of BKCa β4 subunit in the ACC between mCCD (n = 6) and sham (n = 6) rats on postsurgical day 3, 7, 14. e, Representative Western blots for BKCa α and BKCa β4 subunit in the ACC obtained on postsurgical day 7. f, Quantification of the protein levels of α and β4 subunits in the ACC between mCCD (n = 3) and sham (n = 3) rats on postoperative day 7. *p < 0.05, **p < 0.01 compared with that of sham group

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