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Fig. 7 | Molecular Brain

Fig. 7

From: Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors

Fig. 7

NS1619 decreased the increased AMPA receptor-mediated sEPSC frequency of ACC neurons in mCCD rats. a, Representative sEPSCs recorded in ACC pyramidal neuron in slices from sham and mCCD rats at a holding potential of − 60 mV; b, Cumulative interevent interval (top) and amplitude (bottom) histograms of sEPSCs; f, Summary plots of mean sEPSC peak frequency and amplitude (n = 13 neurons for sham and n = 16 neurons for mCCD). c, Representative traces show AMPA receptor-mediated sEPSCs in the presence of paxilline (10 μM) in sham rats and those in the presence of NS1619 (10 μM) in mCCD rats; d, Cumulative interevent interval and amplitude histograms of sEPSCs in the presence of paxilline (10 μM) in sham rats; e, Cumulative interevent interval and amplitude histograms of sEPSCs of ACC neurons in the presence of NS1619 in mCCD rats; f, Summary plots of sEPSC peak frequency and amplitude in the presence of paxilline (10 μM) in sham rats and those in the presence of NS1619 (10 μM) in mCCD rats(n = 13 neurons for sham and n = 16 neurons for mCCD). *p < 0.05, compared to the value of sham group, #p < 0.05, ##p < 0.01 compared with that of mCCD group

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Molecular Brain

ISSN: 1756-6606