Fig. 6
From: Posterior parietal cortex mediates fear renewal in a novel context
Optogenetic inhibition of the posterior parietal cortex (PPC) attenuates fear renewal in a novel context. a, Schematic diagram showing the experimental procedure for fear renewal with optogenetic manipulation. b, Percentage of freezing behavior across the conditioning, extinction and renewal sessions. No significant changes were noted in fear responses to the conditioned stimulus (CS) during fear conditioning and extinction before optogenetic manipulation. On the day of fear renewal, fear response is significantly blocked during a light-on trial, but not a light-off trial. Each dot represents the level of freezing when the CS was presented, except the first dot of each session, which shows the pre-CS baseline. c, Photo-inactivation of the PPC significantly impairs fear renewal in a novel context. d, Representative image of viral expression in the PPC. FC, fear conditioning; EXT, extinction; REN, renewal; BL, baseline; ON, light on trial; OFF, light off trial; ***P < 0.0001