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Fig. 5 | Molecular Brain

Fig. 5

From: Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Fig. 5

Identification of differentially expressed genes (DEGs) by RNA sequencing analysis. a Number of DEGs in the RNA-seq data, adjusted p-value (p-adj) < 0.05. The number of genes with p-adj < 0.05 in NT was 119, and 79 genes in HPF from a total of 58,825 annotated genes. b The Venn diagrams of up-regulated or down-regulated genes in SBMA (p-adj < 0.05). Up-regulation of 107 genes and down-regulation of 73 genes are shown. c The heatmap of the hierarchical clustering analysis based on the DEGs with p-adj < 0.05 in NT. Red represents higher expression and green indicates lower expression. For the list of the genes, see also Additional file 3: Table S1. d The heatmap of hierarchical clustering analysis based on the DEGs with p-adj < 0.05 in HPF. Red represents higher expression and green indicates lower expression. For the list of the genes, see also Additional file 3: Table S2

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Molecular Brain

ISSN: 1756-6606