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Table 2 Hippocampal biomarkers that were significantly different (q < 0.05) both in 8 and 12 months

From: Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer’s disease animal model

MetabolitesRegulationa8 M12 MMassRTIon modeFragment ion (m/z)
q-valuep-valueq-valuep-value(m/z)(min)
Nicotinamidebdown0.001610.000440.001610.00044123.05540.97POS80.0502, 78.0339, 96.0439
LysoPC (16:0)bup1.62E-051.52E-061.62E-051.52E-06496.340212.14POS184.0735, 104.1076
LysoPC (18:0)bup5.07E-071.09E-085.07E-071.09E-08524.371912.61POS184.0739, 104.1074
Phosphatidic acidcup2.01E-052.22E-062.01E-052.22E-06487.279512.61POS445.2678
AMPadown4.10E-068.02E-074.10E-068.02E-07346.05450.97NEG96.9692, 134.0466, 150.9503
LysoPE (16:0)cup1.67E-072.10E-081.67E-072.10E-08452.276111.98NEG255.2324, 112.9855, 196.0417
LysoPE (16:0)aup5.52E-085.39E-095.52E-085.39E-09452.277212.1NEG255.2326, 122.9857, 196.0413
LysoPE (18:0)cup1.37E-062.20E-071.37E-062.20E-07480.308512.13NEG255.2322
  1. aUp- or down- regulation in 5xFAD vs. WT. b identified metabolite compared with authentic standard. cputative metabolites compared with database. RT Retention time, CE Colision energy