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Fig. 2 | Molecular Brain

Fig. 2

From: Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes

Fig. 2

PV-Pten-Het mice exhibited hyper-locomotion in the open field test. a The schematic diagram of the open field test. b PV-Pten-Het mice traveled a longer distance than PV-Pten-WT mice during the 30-min test (WT: n = 25, Het: n = 17, KO; n = 26; F(2,65) = 7.244, p = 0.001, one-way ANOVA; Het vs. WT: p < 0.001, KO vs. WT: p = 0.236, Tukey’s post hoc test). c When the total distance of PV-Pten mice was analyzed in 5-min time bin, PV-Pten-Het mice displayed hyperlocomotion (p = 0.0012, genotype effect, two-way rmANOVA; Het vs. WT: p < 0.001, KO vs. WT: p = 0.236, Tukey’s post hoc test). d PV-Pten-Het mice exhibited increased travel distance in 30-min home-cage activity (WT: n = 6, Het: n = 8, KO; n = 5; F(2,16) = 12.93, p = 0.0005, one-way ANOVA; Het vs. WT: p = 0.036; KO vs. WT, p = 0.087, Tukey’s post hoc test). e Home-cage activity was analyzed in a 5-min time bin. PV-Pten-Het mice displayed hyperlocomotion in home cages (p = 0.0001, genotype effect, two-way rmANOVA; Het vs. WT: p = 0.0017, KO vs. WT: p = 0.4685, Tukey’s post hoc test). f, g There was no significant difference in total distance moved (d; WT: n = 12, Het: n = 16, KO: n = 19; F(2,44) = 0.313, p = 0.733, one-way ANOVA) or distance moved in 5-min time bin (e) in Sst-Pten mice (p = 0.7002, genotype effect, two-way rmANOVA). h, i In home-cage activity test, there was no difference in the total distance traveled (h; WT: n = 4, Het: n = 17, KO: n = 8; F(2,26) = 0.088, p = 0.9164, one-way ANOVA) or the distance moved in 5-min time bin (i; p = 0.9164, genotype effect, two-way rmANOVA) among the three genotypes of Sst-Pten mice. In b, d, f and h, circles represent data from individual animals, and bar graphs indicate mean + SEM. In c, e, g and i, data are represented as mean ± SEM. *: significant; n.s.: not significant

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