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Fig. 7 | Molecular Brain

Fig. 7

From: Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks

Fig. 7

GD mice exhibit synapse anomalies in CA3. a Cumulative histogram of asymmetrical synapse density in the stratum radiatum of the CA3 region of the hippocampus. Synapse density measured by the dissector method was significantly higher in GD mice (median value, 7 vs. 4, n: number of images examined. n = 37, 40, p = 0.00062, Mann–Whitney U-test). b Cumulative histogram of dendritic spine volume of asymmetrical synapses in the same region. Dendritic spine volume measured with ssTEM/3D reconstruction method was comparable between GD and WT mice (median value, 0.015 vs. 0.015, n: number of spines examined. n = 104, 125, p = 0.23, Mann–Whitney U-test). c Cumulative histogram of PSD area of asymmetrical synapses in the same region. PSD area measured with ssTEM/3D reconstruction method was significantly smaller in GD mice (median value, 0.030 vs. 0.035, n: number of spines examined. n = 104, 125, p = 0.0071, Mann–Whitney U-test). d Representative images of asymmetrical synapses at CA3 region observed by electron microscopy

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