Fig. 8
Marginal anomalies of A/C fiber-pyramidal cell synaptic transmission in CA3. a A/C fiber-pyramidal cell synaptic potentials evoked at the stimulus intensities of 2, 3, 4 and 5 V in WT and GD mice. Scale bar: 10 ms, 1 mV. b Dependence of fiber volley amplitude (left) and EPSP slope (right) on stimulus intensity. Statistically significant interaction between genotype and stimulus intensity was observed for EPSP slopes (two-way repeated measure ANOVA: genotype, F1,20 = 2.02, p = 0.1711; stimulus intensity, F10,200 = 767.49, p < 0.0001; genotype × stimulus intensity; F10,200 = 3.2, p = 0.0008). c Normal paired-pulse facilitation of EPSP slopes. d Mild augmentation of LTP in the mutant mice. High-frequency stimulation (HFS) was delivered at time 0. Sample traces are averages of 30 consecutive EPSPs during baseline and 30 to 40 min after HFS. e Cumulative relative probability distributions of the magnitude of LTP measured at 30 to 40 min after HFS. The number (n) of data represents the number of slices in this figure