Metabolites | MR-Egger | Weighted median | MR-PRESSO | Pleiotropy test | Heterogeneity test | |||||
---|---|---|---|---|---|---|---|---|---|---|
β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | Pintercept | PGlobal test | I2 | P-value | |
Amino acid | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 5-Oxoproline | 0.36(0.18,0.55) | 0.0001 | 0.31(0.18,0.45) | 6.29E-06 | 0.24(0.12,0.35) | 0.0007 | 0.09 | 0.06 | 25% | 0.13 |
 Indolelactate | − 0.11(− 0.27,0.06) | 0.2135 | − 0.11(− 0.23,0.02) | 0.0872 | − 0.09(− 0.17,− 0.02) | 0.0244 | 0.85 | 0.76 | 0% | 0.74 |
Carbohydrate | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Mannitol | -0.01(− 0.07,0.06) | 0.9040 | − 0.02(− 0.06,0.02) | 0.2799 | − 0.03(− 0.06,− 0.01) | 0.0138 | 0.34 | 0.84 | 0% | 0.82 |
Lipid | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 2-Oleoylglycerophosphocholine | − 0.37(− 0.82,0.08) | 0.1067 | 0.21(0.05,0.37) | 0.0117 | 0.18(0.05,0.30) | 0.0141 | 0.26 | 0.01 | 17% | 0.26 |
 2-Palmitoylglycerophosphocholine | 0.06(− 0.11,0.24) | 0.4860 | 0.11(− 0.01,0.23) | 0.0682 | 0.14(0.04,0.25) | 0.0117 | 0.26 |  < 0.01 | 45% |  < 0.01 |
 2-Stearoylglycerophosphocholine | − 0.01(− 0.39,0.38) | 0.9734 | 0.11(− 0.01,0.22) | 0.0554 | 0.11(0.03,0.20) | 0.0265 | 0.54 | 0.43 | 4% | 0.41 |
 1-Oleoylglycerol (1-monoolein) | − 0.01(− 0.33,0.32) | 0.9753 | 0.07(− 0.01,0.16) | 0.0937 | 0.09(0.01,0.17) | 0.0533 | 0.57 |  < 0.01 | 62% |  < 0.01 |
 Dihomo-linoleate (20:2n6) | − 0.33(− 0.66,− 0.01) | 0.0494 | − 0.17(− 0.32,− 0.02) | 0.0236 | − 0.14(− 0.25,− 0.04) | 0.0293 | 0.24 | 0.17 | 0% | 0.92 |
 Docosapentaenoate (22:5n3) | 0.18(− 0.03,0.40) | 0.0993 | − 0.16(− 0.28,− 0.03) | 0.0117 | − 0.16(− 0.29,− 0.03) | 0.0414 |  < 0.01 |  < 0.01 | 71% |  < 0.01 |
 Linolenate (18:3n3 or 6) | − 0.37(− 0.73,− 0.01) | 0.0414 | − 0.19(− 0.38,− 0.01) | 0.0497 | − 0.20(− 0.38,− 0.03) | 0.0814 | 0.30 | 0.08 | 2% | 0.40 |
 Acetylcarnitine | − 0.17(− 0.54,0.20) | 0.3618 | − 0.23(− 0.39,− 0.07) | 0.0053 | − 0.25(− 0.40,− 0.10) | 0.0044 | 0.66 | 0.01 | 51% |  < 0.01 |
Peptide | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Cyclo(leu-pro) | − 0.09(− 0.19,0.02) | 0.1018 | − 0.03(− 0.10,0.04) | 0.4332 | − 0.06(− 0.12,− 0.01) | 0.0438 | 0.60 | 0.03 | 38% | 0.07 |
Xenobiotics | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Stachydrine | 0.10(− 0.05,0.25) | 0.2068 | 0.04(− 0.02,0.10) | 0.1482 | 0.06(0.02,0.11) | 0.0308 | 0.65 | 0.41 | 11% | 0.35 |
 p-Acetamidophenylglucuronide | 0.01(0.00,0.01) | 0.0075 | 0.01(0.00,0.01) | 0.0060 | 0.01(0.00,0.01) | 0.0454 | 0.06 | 0.06 | 17% | 0.13 |
 Salicyluric glucuronide | 1.00(0.98,1.02) | 0.7825 | 0.99(0.97,1.01) | 0.1379 | 0.99(0.98,0.99) | 0.0373 | 0.05 | 0.48 | 0% | 0.67 |
 Hydroquinone sulfate | 0.97(0.94,1.01) | 0.204 | 0.97(0.94,1.01) | 0.0865 | 0.98(0.96,0.99) | 0.0211 | 0.96 | 0.69 | 0% | 0.69 |