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Table 1 Sensitivity analysis of causal associations between metabolites and intelligence

From: Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study

Metabolites MR-Egger Weighted median MR-PRESSO Pleiotropy test Heterogeneity test
β (95% CI) P-value β (95% CI) P-value β (95% CI) P-value Pintercept PGlobal test I2 P-value
Amino acid           
 5-Oxoproline 0.36(0.18,0.55) 0.0001 0.31(0.18,0.45) 6.29E-06 0.24(0.12,0.35) 0.0007 0.09 0.06 25% 0.13
 Indolelactate − 0.11(− 0.27,0.06) 0.2135 − 0.11(− 0.23,0.02) 0.0872 − 0.09(− 0.17,− 0.02) 0.0244 0.85 0.76 0% 0.74
Carbohydrate           
 Mannitol -0.01(− 0.07,0.06) 0.9040 − 0.02(− 0.06,0.02) 0.2799 − 0.03(− 0.06,− 0.01) 0.0138 0.34 0.84 0% 0.82
Lipid           
 2-Oleoylglycerophosphocholine − 0.37(− 0.82,0.08) 0.1067 0.21(0.05,0.37) 0.0117 0.18(0.05,0.30) 0.0141 0.26 0.01 17% 0.26
 2-Palmitoylglycerophosphocholine 0.06(− 0.11,0.24) 0.4860 0.11(− 0.01,0.23) 0.0682 0.14(0.04,0.25) 0.0117 0.26  < 0.01 45%  < 0.01
 2-Stearoylglycerophosphocholine − 0.01(− 0.39,0.38) 0.9734 0.11(− 0.01,0.22) 0.0554 0.11(0.03,0.20) 0.0265 0.54 0.43 4% 0.41
 1-Oleoylglycerol (1-monoolein) − 0.01(− 0.33,0.32) 0.9753 0.07(− 0.01,0.16) 0.0937 0.09(0.01,0.17) 0.0533 0.57  < 0.01 62%  < 0.01
 Dihomo-linoleate (20:2n6) − 0.33(− 0.66,− 0.01) 0.0494 − 0.17(− 0.32,− 0.02) 0.0236 − 0.14(− 0.25,− 0.04) 0.0293 0.24 0.17 0% 0.92
 Docosapentaenoate (22:5n3) 0.18(− 0.03,0.40) 0.0993 − 0.16(− 0.28,− 0.03) 0.0117 − 0.16(− 0.29,− 0.03) 0.0414  < 0.01  < 0.01 71%  < 0.01
 Linolenate (18:3n3 or 6) − 0.37(− 0.73,− 0.01) 0.0414 − 0.19(− 0.38,− 0.01) 0.0497 − 0.20(− 0.38,− 0.03) 0.0814 0.30 0.08 2% 0.40
 Acetylcarnitine − 0.17(− 0.54,0.20) 0.3618 − 0.23(− 0.39,− 0.07) 0.0053 − 0.25(− 0.40,− 0.10) 0.0044 0.66 0.01 51%  < 0.01
Peptide           
 Cyclo(leu-pro) − 0.09(− 0.19,0.02) 0.1018 − 0.03(− 0.10,0.04) 0.4332 − 0.06(− 0.12,− 0.01) 0.0438 0.60 0.03 38% 0.07
Xenobiotics           
 Stachydrine 0.10(− 0.05,0.25) 0.2068 0.04(− 0.02,0.10) 0.1482 0.06(0.02,0.11) 0.0308 0.65 0.41 11% 0.35
 p-Acetamidophenylglucuronide 0.01(0.00,0.01) 0.0075 0.01(0.00,0.01) 0.0060 0.01(0.00,0.01) 0.0454 0.06 0.06 17% 0.13
 Salicyluric glucuronide 1.00(0.98,1.02) 0.7825 0.99(0.97,1.01) 0.1379 0.99(0.98,0.99) 0.0373 0.05 0.48 0% 0.67
 Hydroquinone sulfate 0.97(0.94,1.01) 0.204 0.97(0.94,1.01) 0.0865 0.98(0.96,0.99) 0.0211 0.96 0.69 0% 0.69
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