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Table 1 Sensitivity analysis of causal associations between metabolites and intelligence

From: Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study

Metabolites

MR-Egger

Weighted median

MR-PRESSO

Pleiotropy test

Heterogeneity test

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

Pintercept

PGlobal test

I2

P-value

Amino acid

          

 5-Oxoproline

0.36(0.18,0.55)

0.0001

0.31(0.18,0.45)

6.29E-06

0.24(0.12,0.35)

0.0007

0.09

0.06

25%

0.13

 Indolelactate

− 0.11(− 0.27,0.06)

0.2135

− 0.11(− 0.23,0.02)

0.0872

− 0.09(− 0.17,− 0.02)

0.0244

0.85

0.76

0%

0.74

Carbohydrate

          

 Mannitol

-0.01(− 0.07,0.06)

0.9040

− 0.02(− 0.06,0.02)

0.2799

− 0.03(− 0.06,− 0.01)

0.0138

0.34

0.84

0%

0.82

Lipid

          

 2-Oleoylglycerophosphocholine

− 0.37(− 0.82,0.08)

0.1067

0.21(0.05,0.37)

0.0117

0.18(0.05,0.30)

0.0141

0.26

0.01

17%

0.26

 2-Palmitoylglycerophosphocholine

0.06(− 0.11,0.24)

0.4860

0.11(− 0.01,0.23)

0.0682

0.14(0.04,0.25)

0.0117

0.26

 < 0.01

45%

 < 0.01

 2-Stearoylglycerophosphocholine

− 0.01(− 0.39,0.38)

0.9734

0.11(− 0.01,0.22)

0.0554

0.11(0.03,0.20)

0.0265

0.54

0.43

4%

0.41

 1-Oleoylglycerol (1-monoolein)

− 0.01(− 0.33,0.32)

0.9753

0.07(− 0.01,0.16)

0.0937

0.09(0.01,0.17)

0.0533

0.57

 < 0.01

62%

 < 0.01

 Dihomo-linoleate (20:2n6)

− 0.33(− 0.66,− 0.01)

0.0494

− 0.17(− 0.32,− 0.02)

0.0236

− 0.14(− 0.25,− 0.04)

0.0293

0.24

0.17

0%

0.92

 Docosapentaenoate (22:5n3)

0.18(− 0.03,0.40)

0.0993

− 0.16(− 0.28,− 0.03)

0.0117

− 0.16(− 0.29,− 0.03)

0.0414

 < 0.01

 < 0.01

71%

 < 0.01

 Linolenate (18:3n3 or 6)

− 0.37(− 0.73,− 0.01)

0.0414

− 0.19(− 0.38,− 0.01)

0.0497

− 0.20(− 0.38,− 0.03)

0.0814

0.30

0.08

2%

0.40

 Acetylcarnitine

− 0.17(− 0.54,0.20)

0.3618

− 0.23(− 0.39,− 0.07)

0.0053

− 0.25(− 0.40,− 0.10)

0.0044

0.66

0.01

51%

 < 0.01

Peptide

          

 Cyclo(leu-pro)

− 0.09(− 0.19,0.02)

0.1018

− 0.03(− 0.10,0.04)

0.4332

− 0.06(− 0.12,− 0.01)

0.0438

0.60

0.03

38%

0.07

Xenobiotics

          

 Stachydrine

0.10(− 0.05,0.25)

0.2068

0.04(− 0.02,0.10)

0.1482

0.06(0.02,0.11)

0.0308

0.65

0.41

11%

0.35

 p-Acetamidophenylglucuronide

0.01(0.00,0.01)

0.0075

0.01(0.00,0.01)

0.0060

0.01(0.00,0.01)

0.0454

0.06

0.06

17%

0.13

 Salicyluric glucuronide

1.00(0.98,1.02)

0.7825

0.99(0.97,1.01)

0.1379

0.99(0.98,0.99)

0.0373

0.05

0.48

0%

0.67

 Hydroquinone sulfate

0.97(0.94,1.01)

0.204

0.97(0.94,1.01)

0.0865

0.98(0.96,0.99)

0.0211

0.96

0.69

0%

0.69