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Fig. 3 | Molecular Brain

Fig. 3

From: NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice

Fig. 3

The GluN2C/2D components of the NMDAR-mediated EPSCs are significant in neurons of the CA1 by using UBP145 as antagonist of GluN2C/2D. a UBP145 partially inhibited NMDAR-mediated EPSCs in the CA1. Left: traces show the currents at different time points during application of drugs. UBP145 produced its maximal effect at 20 min after bath application (n = 4 neurons/3 mice). Right: Summary of the partial inhibition of the UBP145 on the NMDAR-mediated current. Data within the last five minutes of the baseline, UBP145 application and washout phase is averaged. Open circles represent the individual data points. b Summarized data of the effect of UBP145 to the rising time (left) and decay time (right) of the NMDAR-mediated EPSCs in the CA1 neurons. The application of UBP145 produced a significant inhibitory effect on the decay time of EPSCs. **p < 0.01. ***p < 0.001. Error bars represent SEM

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