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Fig. 6 | Molecular Brain

Fig. 6

From: NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice

Fig. 6

NMDAR modulates spontaneous presynaptic release in the ACC. a Top: Representative traces of the mEPSCs recorded in the ACC neurons before and after applying a high dose of AP-5 (200 μM). Middle: Cumulative fraction of inter-event interval (left) and amplitude (right) of the mEPSCs in the phase of baseline (black line), AP-5 application (red line) and wash out (blue line). Bottom: Statistic results of the frequency (left) and amplitude (right) of mEPSCs (n = 9 neurons/6 mice). b Top: Representative traces of the mEPSCs recorded in the ACC neurons before and after applying a lower dose of AP-5 (50 μM). Middle: Cumulative fraction of inter-event interval (left) and amplitude (right) of the mEPSCs in the phase of baseline (black line), AP-5 application (red line) and wash out (blue line). Bottom: Statistic results of the frequency (left) and amplitude (right) of mEPSCs (n = 9 neurons/6 mice). Open circles represent the individual data points. *p < 0.05, error bars indicated SEM

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Molecular Brain

ISSN: 1756-6606