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Fig. 7 | Molecular Brain

Fig. 7

From: NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice

Fig. 7

GluN2C/2D modulate spontaneous presynaptic release in the ACC. a Top: Representative traces of the mEPSCs recorded in the ACC neurons before and after applying PEAQX (0.4 μM), a selective antagonist of GluN2A. Bottom: Statistic results of the frequency (left) and amplitude (right) of mEPSCs (n = 5 neurons/3 mice). b Top: Representative traces of the mEPSCs recorded in the ACC neurons before and after applied Ro 25-6981 (3 μM), a selective antagonist of GluN2B. Bottom: Statistic results of the frequency (left) and amplitude (right) of mEPSCs (n = 7 neurons/6 mice). c Top: Representative traces of the mEPSCs recorded in the ACC neurons before and after applying UBP145 (3 μM). Bottom: Statistic results of the frequency (left) and amplitude (right) of mEPSCs (n = 10 neurons/4 mice). d Top: Representative traces of the mEPSCs recorded in the ACC neurons before and after applied PPDA (10 μM). Bottom: Statistic results of the frequency (left) and amplitude (right) of mEPSCs (n = 5 neurons/3 mice). Open circles represent the individual data points. *p < 0.05, error bars indicated SEM

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