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Fig. 3 | Molecular Brain

Fig. 3

From: The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function

Fig. 3

Gating properties of CaV2.1 (Δ47), Y1384C (Δ47), CaV2.1 (+ 47) and Y1384C (+ 47) channels. a Voltage-dependence of activation for cells expressing CaV2.1 (Δ47) and Y1384C (Δ47) channels. Inset: mean half-activation potential values. b Voltage-dependence of steady-state inactivation for CaV2.1 (Δ47) and Y1384C (Δ47) channels. Inset: mean half-inactivation potential values. c Window current of CaV2.1 (Δ47) and Y1384C (Δ47) variants. Conductance and steady-state inactivation curves were obtained using the values from the fit with Boltzmann functions. d Voltage-dependence of activation for cells expressing CaV2.1 (+ 47) and Y1384C (+ 47) channels. Inset: mean half-activation potential values. e Voltage-dependence of steady-state inactivation for CaV2.1 (+ 47) and Y1384C (+ 47) channels. Inset: mean half-inactivation potential values. f Window current of CaV2.1 (+ 47) and Y1384C (+ 47) variants. The numbers in parentheses represent the numbers of cells recorded. Asterisks denote significance *0.05, **0.01, ***0.001 levels (One-way ANOVA and Tukey’s multiple comparison test, with a single pooled variance test)

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