Fig. 1

Loss of the Prdx6 gene caused fast learning and enhanced fear memories. a General procedure for trace fear conditioning: Habituation of mice in the chamber was performed for 3 consecutive days. The next day, mice were conditioned with three tone and shock pairs. Contextual fear memories were tested 24 h later, followed by a tone test to evaluate cue fear memory (n = 14/group). b The learning curve for baseline and three trials of TFC indicated both groups of mice learnt normally though significant differences appeared in trial 2. c Total freezing percentage of Prdx6^+/+ or Prdx6^−/− mice during the training session. d Total freezing percentage during the contextual test of mice. e Total freezing percentage during the tone test of mice. All data represent the mean ± the SEM. *p < 0.05. TFC trace fear conditioning