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Fig. 2 | Molecular Brain

Fig. 2

From: Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway

Fig. 2

Intraventricular injection of mouse PRDX6 (mPRDX6) lentiviruses attenuated enhanced contextual fear memory of Prdx6−/− mice. a The procedure for the overexpression study. Mice were injected with lentivirus and housed for 2 weeks before performing trace fear conditioning. b Representative image of cannula tip position (red) in the right lateral ventricle. c The schematic lentivirus construct pLAS3w. Ppuro contains either EGFP or mPRDX6. d The learning curve of baseline and after each tone-shock pair (n = 10/group). e Total freezing percentage of Prdx6+/+ and Prdx6−/− mice during the training session. f Total freezing percentage during the contextual test of mice. g Total freezing percentage of the mice during the tone test. h mPRDX6 expression across the different subregions in the hippocampus of Prdx6−/− mice. All data represent the mean ± the SEM. *p < 0.05. TFC trace fear conditioning, LV-mPRDX6 lentivirus containing mouse PRDX6

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