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Fig. 4 | Molecular Brain

Fig. 4

From: Caveolin-1 deficiency impairs synaptic transmission in hippocampal neurons

Fig. 4

Synaptic vesicle endocytosis kinetics are slowed in Cav1-KD neurons. a, d Representative traces of Physin-pH responses to 100 APs (a) and 300 APs (d) in Control and Cav1-KD neurons. Neurons transfected with Physin-pH with or without shRNA-Cav1 were stimulated with 100 or 300 APs at 10 Hz. b, e The traces of Physin-pH responses to 100 APs (b) and 300 APs (e) were projected to the semi-log scale for clearance. (C, D) Quantification of post-stimulus endocytic time constants, expressed as means ± SEMs in (c) Control (τendo, 13.71 ± 0.92; n = 14 cells) and Cav1-KD (τendo, 20.29 ± 2.99; n = 9 cells) neurons stimulated with 100 APs, and (d) Control (τendo, 18.04 ± 1.90; n = 14 cells) and Cav1-KD (τendo, 28.21 ± 5.28; n = 9 cells) neurons stimulated with 300 APs (*p < 0.05)

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