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Fig. 5 | Molecular Brain

Fig. 5

From: The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice

Fig. 5

Decreased density of VGAT puncta in the ML of the PHY2S19X/S19X cerebellum and impairment of motor coordination in PHY2S19X/S19X mice. a, b Sagittal sections of P21 WT (a) and PHY2S19X/S19X (b) mice cerebella immunolabeled with an anti-VGAT antibody. Scale bars: 20 µm. c Density of VGAT puncta in the ML of WT (white, n = 31) and PHY2S19X/S19X (black, n = 30) mice at P21. d Density of DAPI positive cells in the ML of WT (white, n = 38) and PHY2S19X/S19X (black, n = 48) mice at P21. e Fall latency in the rotarod test for WT (white, n = 11) and PHY2S19X/S19X (black, n = 8) mice at postnatal week 10–11. Data for the 4 days of evaluation is shown. *P = 0.0334, repeated measures ANOVA. The error bars indicate the s.e.m. ***P < 0.001, Student’s t test. *P < 0.05, repeated measures ANOVA

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