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Fig. 1 | Molecular Brain

Fig. 1

From: Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation

Fig. 1

Impaired pattern separation in Tg2576 mice. A Experimental procedure for pattern separation in 10-week-old WT and Tg2576 mice. Ba On day 4 to 5, the kinetics of freezing across the 5 min test in context A. Bb Percentage of freezing in context A (filled bar) and context B (open bar) during day 4–5. WT (blue, n = 8) and Tg2576 (green, n = 9) mice displayed equal amounts of freezing in both contexts A and B. Ca On day 6 to 13, time course of the discrimination ratio in WT (blue, n = 8) and Tg2576 (green, n = 7) mice. Statistical significance for each day was tested using ANOVA (*P < 0.05; **P < 0.01; *** P < 0.001). Cb Percentage of freezing in context A (filled bar) and context B (open bar) for WT (blue, n = 8) and Tg2576 (green, n = 7) mice on day 11. Freezing levels were compared between the two contexts for each group (N.S., no statistical significance; *P < 0.05). Da Experimental procedure for one-trial contextual fear conditioning between WT (n = 8) and Tg2576 (n = 7) mice. Db The percentage of freezing in context A (filled bar) and context C (open bar, distinct object) for WT (n = 8) and Tg2576 (n = 7) mice

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