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Fig. 3 | Molecular Brain

Fig. 3

From: Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation

Fig. 3

Voltage-dependent K+ currents in the WT and Tg2576. Aa Superimposed current traces evoked by various steps of depolarization (− 60 mV to + 30 mV in 10 mV step) for 1 s from the holding potential of − 70 mV in the WT (blue) and Tg2576 (green) dentate GCs. Ab Amplitudes of peak currents (Ipeak) and steady state currents (Iss) measured at the end of depolarization are plotted as a function of the given potential (V). WT (closed blue circle, n = 9) and Tg2576 (closed green circle, n = 7). Ba The difference in currents before and after applying 5 mM 4-AP (I4-AP) in the WT (blue) and Tg2576 (green) dentate GCs. Bb Ipeak and Iss for I4-AP are plotted as a function of the given potential (V). WT (closed blue circle, n = 9) and Tg2576 (closed green circle, n = 7). Ca I4-AP traces obtained at + 30 mV are averaged (WT, blue, n = 9; Tg2576, green, n = 7) and superimposed. Cb I4-AP recorded at + 30 mV were fitted to double-exponential functions. Amplitude and time constant for the fast component (Afast, τfast) and the slow component (Aslow, τslow). Mean ± S.E.M., **, P < 0.01, ***, P < 0.001. N.S. not significantly different, P > 0.05

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