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Fig. 4 | Molecular Brain

Fig. 4

From: Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation

Fig. 4

Downregulation of Kv4.1 expression in Tg2576 causes hyperexcitability of Tg2576 GCs. A mRNA expression levels for Kv4 family channels in the WT (blue) and Tg2576 (green) DG detected by quantitative RT-PCR. B Western blot analysis for Kv4.1 in DG of 8-week-old mice. For a loading control, β-actin was used. Right, Kv4.1expression in Tg2576 was significantly smaller than WT mice. *, P < 0.05. Ca Example traces of APs evoked by 200 pA current injection immediate (3 min, blue for WT and green for Tg2576) and 15 min (red) after brake-in of patch pipettes containing Kv4.1 antibody. Cb Firing frequency at 200 pA is compared in each conditions

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