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Fig. 7 | Molecular Brain

Fig. 7

From: Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders

Fig. 7

Sleep and wakefulness cycle in Del(3.0 Mb)/+ mice. a–c Circadian variation in wakefulness (a), NREM sleep (b) and REM sleep (c) in Del(3.0 Mb)/+ mice (n = 9 for WT; n = 16 for Del(3.0 Mb)/+ mice). Data are expressed as minutes per hour spent in each stage, averaged from EEG/EMG recordings during two consecutive 24-h periods. d Total time of wakefulness, NREM sleep and REM sleep stages in 24-h period, light period (L) and dark period (D). e Episode duration of wakefulness, NREM sleep and REM sleep stages in 24-h period, light period and dark period. f REM latency in 24-h period, light period and dark period. g REM interval in 24-h period, light period and dark period. h Values indicate the number of transitions between wakefulness, NREM sleep and REM sleep per 24 h. i–k EEG spectral profiles of WT (blue line, n = 9) and Del(3.0 Mb)/+ mice (red line, n = 16) during wakefulness (i), NREM sleep (j) and REM sleep (k). The average EEG spectra were normalized to total EEG power from 1 to 32 Hz in 1 Hz bins. Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001

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