Fig. 5
MK-801-induced hyperactivity in mGlu5−/− mice and wild-type littermates at PND21 and PND75. Locomotor activity in response to 0.32 mg/kg or 0.64 mg/kg MK-801 at PND21 and in response to 0.32 mg/kg or 0.64 mg/kg MK-801 at PND75 is shown in a–d. Mice were habituated to the environment for 60 min prior to the i.p. injection of MK-801. Values are means ± S.E.M. of 10 wild-type and 3 mGlu5−/− mice in a, 5 wild-type and 6 mGlu5−/− mice in b, 7 wild-type and 5 mGlu5−/− mice in c, 7 wild-type and 4 mGlu5−/− mice in d. Open bars = habituation phase; closed bars = response to MK-801. *p < 0.05 vs. wild-type mice (One-way ANOVA for repeated measures). b, F1,119 = 27.875; p < 0.001; c F1,119 = 44.692; p < 0.001