Skip to main content
Fig. 6 | Molecular Brain

Fig. 6

From: Activation of acid‐sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation

Fig. 6

A hypothesized model of how CO2 inhalation and ASICs regulate protein degradation after memory retrieval. CO2 inhalation decreases the brain pH during memory retrieval. The low pH activates ASICs on the postsynaptic membrane, results in the increase of intracellular Ca2+. Then Ca2+ can bind to its binding proteins and facilitate the ubiquitination process and eventually the polyubiquitinated GluR2 was degraded by the proteasome or other enzymes. The lack of GluR2 in the new synthesized AMPARs indicated the outcomes of the exchange of CI-AMPARs to CP-AMPARs

Back to article page

Molecular Brain

ISSN: 1756-6606