Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

Table 2 ANOVAs for pain-relevant characteristics in fibromyalgia subjects

	Effect	df_Num, df_Den	MSE	F	η²_G	p
Pain duration
	5‐HT_1A	1, 74	10,091	0.41	0.005	0.523
	5-HTT	2, 74	10,091	1.34	0.033	0.268
	5‐HT_1A*5‐HTT	2, 74	10,091	1.79	0.044	0.174
VASnow
	5‐HT_1A	1, 75	477.05	0.364	0.005	0.548
	5-HTT	2, 75	477.05	0.369	0.009	0.693
	5‐HT_1A*5‐HTT	2, 75	477.05	0.903	0.023	0.410
PCS
	5‐HT_1A	1, 74	116.77	1.66	0.021	0.201
	5-HTT	2, 74	116.77	1.38	0.034	0.258
	5‐HT_1A*5‐HTT	2, 74	116.77	1.37	0.034	0.260
HAD-A
	5‐HT_1A	1, 75	18.68	1.377	0.0168	0.244
	5-HTT	2, 75	18.68	0.932	0.0228	0.398
	5‐HT_1A*5‐HTT	2, 75	18.68	1.809	0.0443	0.171
HAD-D
	5‐HT_1A	1, 75	11.90	5.05	0.045	0.028
	5-HTT	2, 75	11.90	3.92	0.070	0.024
	5‐HT_1A*5‐HTT	2, 75	11.90	11.68	0.210	< 0.001
BDI
	5‐HT_1A	1, 74	49.72	3.59	0.034	0.062
	5-HTT	2, 74	49.72	5.63	0.106	0.005
	5‐HT_1A*5‐HTT	2, 74	49.72	8.67	0.163	< 0.001
FIQ
	5‐HT_1A	1, 75	269.59	0.03	0.001	0.870
	5-HTT	2, 75	269.59	1.34	0.032	0.268
	5‐HT_1A*5‐HTT	2, 75	269.59	2.86	0.069	0.064

PCS Pain Catastrophizing Scale, VASnow current pain on visual analogue scale, HAD-A Hospital Anxiety and Depression Scale (anxiety subscale), HAD-D Hospital Anxiety and Depression Scale (depression subscale), BDI Beck’s Depression Inventory, FIQ Fibromyalgia Impact Questionnaire, df_Num numerator degree of freedom, df_Den denominator degrees of freedom, MSE mean square error, η²_G generalized eta-squared. Effects significant at p < 0.05 are depicted in bold

ISSN: 1756-6606