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Fig. 3 | Molecular Brain

Fig. 3

From: Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

Fig. 3

The amount of sphingolipids was altered in the brains of gba1 and gba2 mutant medaka. a The amount of GlcCer was increased in gba1/gba2 DKO medaka compared with gba1 KO medaka (n = 3 for each genotype). b The amount of GalCer did not differ markedly between gba1 KO and gba1/gba2 DKO medaka (n = 3 for each genotype). c The amount of ceramide did not differ among genotypes (n = 3 for each genotype). d The amount of sphingosine did not differ markedly between gba1 KO and gba2 KO medaka (n = 3 for each genotype). e The amount of GlcSph was increased in gba1/gba2 DKO compared with gba1 KO medaka (n = 3 for each genotype). f The amount of GalSph was increased in gba1 KO and gba1/gba2 DKO medaka compared with WT medaka (n = 3 for each genotype). A one-way ANOVA with Tukey's multiple comparison test was performed. N.D.: not detected (below the detection threshold). n.s. not significant, *p < 0.05, **p < 0.01 and ***p < 0.001. The bars indicate the mean ± SEM

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