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Fig. 2 | Molecular Brain

Fig. 2

From: Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss

Fig. 2

Mitochondrial stress accelerates hearing loss in Cdk5rap1-KO mice. a Auditory brainstem response thresholds in Cdk5rap1-knockout (KO) mice at 4, 12, 20, or 32 weeks of age compared to those in littermate control (CNT) mice at different frequencies (n = 5 for each genotype). Error bars represent the mean ± SE of five independent experiments analyzed using the Tukey test. *P < 0.05, **P < 0.01, ***P < 0.001. N.S. not significant. b Distortion-product otoacoustic emissions threshold at different frequencies in Cdk5rap1-KO mice at 4, 12, 20, or 32 weeks of age compared to those in CNT mice (n = 5 for each genotype). Error bars represent the mean ± SE of five independent experiments analyzed using the Tukey test. *P < 0.05, **P < 0.01, ***P < 0.001. N.S. not significant. c Illustration of a cross-section through a mouse cochlea cut along its longitudinal axis. SGCs spiral-ganglion cells, OC organ of Corti, SV stria vascularis, SLi spiral ligament. The blue and red boxes represent a single half-turn of the cochlea and the zoomed-in view of the OC, respectively. Red arrows indicate specific cell types: inner and outer hair cells. The inner and outer hair cells act as mechanoelectrical transducers and play a crucial role in hearing. The electrical signal is transmitted via the SGCs to the auditory pathway of the brain. d Gross morphologies of KO or CNT cochleae (n = 5 for each genotype). White boxes indicate the cochlear middle turn. e Morphology of the cochlear middle turn in KO or CNT mice at 4, 12, 20, or 48 weeks (n = 5 for each genotype). Scale bar = 100 µm

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