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Fig. 4 | Molecular Brain

Fig. 4

From: Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss

Fig. 4

Cochlear senescence in SGCs and stria vascularis (SV) cells of Cdk5rap1-KO mice. a Sections of cochlea stained with senescence-associated β-gal (SA-β-gal) in Cdk5rap1-knockout (KO) and littermate control (CNT) mice at 4, 12, 20, or 48 weeks of age. Senescence-positive cells appear blue. SGCs spiral-ganglion cells, OC organ of Corti, SV stria vascularis, SLi spiral ligament. Scale bar = 100 µm. b SA-β-gal-positive ratio in the cochleae of KO or CNT mice (n = 5 for each genotype). c Magnified image of the middle cochlear turn illustrating the distribution of senescent cells. Scale bar = 100 µm. d SA-β-gal-positive ratio in the separate areas of KO and CNT cochlea (n = 5 for each genotype)

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