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Fig. 3 | Molecular Brain

Fig. 3

From: Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

Fig. 3

Quantification of LC3B-II and TOM20 proteins in WT and Ts1Cje hippocampus. Hippocampal proteins from WT and Ts1Cje mice pairs were analyzed in Western blot with anti-LC3B or anti-TOM20 antibody. A LC3B western blot showing WT and Ts1Cje littermate pairs analyzed and total protein loaded. The ratio LC3B-II/LC3B-I is shown as the mean ± SEM (WT: 0.8714 ± 0.04154; Ts1Cje: 0.6500 ± 0.06802; p = 0.0152, Student’s t-test, n = 7 for WT and n = 6 for Ts1Cje). B TOM20 western blot showing WT and Ts1Cje littermate pairs analyzed and total protein loaded. The signals were normalized to the corresponding total protein loaded and the mean ± SEM values are shown (WT: 1.024 ± 0.08799; Ts1Cje: 1.412 ± 0.1452; p = 0.0414, Student’s t-test, n = 7 animals per genotype)

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Molecular Brain

ISSN: 1756-6606