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Fig. 7 | Molecular Brain

Fig. 7

From: Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

Fig. 7

mGluR-LTD in hippocampal slices of Ts1Cje mice treated with rapamycin prenatally. A Time course of DHPG effects on field excitatory postsynaptic potentials (fEPSP) in Ts1Cje mice treated with rapamycin prenatally (Ts1Cje RAPA) and control Ts1Cje mice (same data as in Fig. 4). Upper insets: representative traces of a fEPSP before (1, 2) and after (1ʹ, 2ʹ) DHPG application in Ts1Cje (1, 1ʹ; same data as in Fig. 4) and Ts1Cje RAPA (2, 2ʹ) mice. The mean fEPSP slopes before DHPG perfusion between Ts1Cje and Ts1Cje RAPA mice were not different. B Quantification of the effects depicted in A. The error bars represent the SEM. The number of slices for each condition is indicated in the corresponding bar (Ts1Cje: 7 slices from 3 mice; Ts1Cje RAPA: 7 slices from 4 mice). p < 0.001 Student’s t-test

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Molecular Brain

ISSN: 1756-6606