Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

Urbano-Gámez, Jesús David; Casañas, Juan José; Benito, Itziar; Montesinos, María Luz

doi:10.1186/s13041-021-00795-6

Molecular Brain

Table 2 Proteins involved in synaptic plasticity pathways affected in Ts1Cje SNs

From: Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

Symbol	Entrez gene name	ID	Ts1Cje	Pathway
ADCY9	Adenylate cyclase 9	P51830	1.344	CREB signaling Endocannabinoid neuronal synapse
ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	O55143	1.251	Calcium signaling
ATP2B1	ATPase plasma membrane Ca2+ transporting 1	G5E829	1.329	Calcium signaling
ATP2B2	ATPase plasma membrane Ca2+ transporting 2	F8WHB1	1.268	Calcium signaling
CACNA1A	Calcium voltage-gated channel subunit alpha1 A	P97445	1.314	Calcium signaling CREB signaling Endocannabinoid neuronal synapse Synaptic LTD
CACNA1G	Calcium voltage-gated channel subunit alpha1 G	Q5SUF8	1.474	Calcium signaling CREB signaling Endocannabinoid neuronal synapse Synaptic LTD
CACNA2D1	Calcium voltage-gated channel auxiliary subunit alpha2delta 1	O08532	1.262	Calcium signaling CREB signaling Endocannabinoid neuronal synapse Synaptic LTD
GNB2	G protein subunit beta 2	E9QKR0	1.207	CREB signaling
GNG2	G protein subunit gamma 2	P63213	− 1.212	CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling
GRIA2	Glutamate ionotropic receptor AMPA type subunit 2	P23819	1.481	Calcium signaling CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling Synaptic LTD
GRIA4	Glutamate ionotropic receptor AMPA type subunit 4	Q9Z2W8	− 1.251	Calcium signaling CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling Synaptic LTD
GRIN1	Glutamate ionotropic receptor NMDA type subunit 1	A2AI21	1.758	Calcium signaling CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling
GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B	Q01097	1.371	Calcium signaling CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling
GRM5	Glutamate metabotropic receptor 5	Q3UVX5	1.200	CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling Synaptic LTD
RAP2B	RAP2B. member of RAS oncogene family	P61226	1.300	Calcium signaling CREB signaling Synaptic LTD
RYR2	Ryanodine receptor 2	E9Q401	1.251	Calcium signaling Synaptic LTD

The relative amounts (fold change, compared to WT SNs) of these proteins in Ts1Cje SNs are shown

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ISSN: 1756-6606

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