Fig. 1
From: Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation
Cocaine-induced Egr3 binding to promoters of mitochondrial-related nuclear gene in NAc. A Illustration of the ChIP assay using anti-Egr3 to immunoprecipitate chromatin in NAc tissue. B Top panel: The timeline of cocaine (20 mg/kg, i.p.) or saline injections and NAc tissue collection after 24-h abstinence. Bottom panel: Egr3 binding is increased on Drp1, Nrf2 and Polγ gene promoters in NAc in the cocaine group (n = 35 mice, 7 samples) compared to saline injected in male (n = 30, 6 samples) mice. Student’s t test, *p < 0.05; Error bars, SEM