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Fig. 8 | Molecular Brain

Fig. 8

From: APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains

Fig. 8

Upstream regulators implicated in the proteomic changes observed in the cerebrovasculature of the inferior frontal gyrus between Alzheimer's disease (AD) patients and controls from different APOE genotype backgrounds. Histograms shows Top 5 significantly altered upstream regulators identified by ingenuity pathway analyses between AD vs  controls from APOE2/E3 (A), APOE3/E3 (B), APOE3/E4 (C) and APOE4/E4 (D) genotypes. Data represents negative Log10 of the FDR adjusted “overlap” P value after Fischer’s test and Benjamin Hochberg correction. Overlap P values are generated based on the significant overlap between dataset proteins/genes and known targets regulated by a transcription factor/upstream regulator. Cut of level for significantly altered upstream regulators was set at \(\ge\) 2 (i.e. −log 10[P value])

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Molecular Brain

ISSN: 1756-6606