Table 1 List of control and Alzheimer’s disease cases, their demographics, APOE genotype, and randomization of samples for Tandem Mass Tag isobaric 10-plex multiplexing
DX | APOE genotype | Mean age [years] | Male | Female | N per group | TMT 10 Plex labels |
|---|---|---|---|---|---|---|
Control | E2/E2 | 71.5 ± 8.58 | 33.3% (2/6) | 66.7% (4/6) | 6 | TMT − 126 |
Control | E2/E3 | 80 ± 5.85 | 50% (3/6) | 50% (3/6) | 6 | TMT -127N |
Control | E3/E3 | 83 ± 3.04 | 100% (6/6) | 0% (0/6) | 6 | TMT -127C* (denominator) |
Control | E3/E4 | 84.17 ± 3.64 | 60% (3/5) | 40% (2/5) | 5 | TMT -128N |
Control | E4/E4 | 45.83 ± 4.39 | 66.7% (4/6) | 33.3% (2/6) | 6 | TMT -128C |
AD | E2/E2 | 90 ± 17.0* | 0% (0/3) | 100% (3/3) | 3 | TMT -129N |
AD | E2/E3 | 89 ± 4.14 | 66.7% (4/6) | 33.3% (2/6) | 6 | TMT -129C |
AD | E3/E3 | 87 ± 3.27 | 16.67% (1/6) | 83% (5/6) | 6 | TMT -130N |
AD | E3/E4 | 78.5 ± 3.60 | 50% (3/6) | 50% (3/6) | 6 | TMT -130C |
AD | E4/E4 | 84.8 ± 4.55 | 40% (2/5) | 60% (3/5) | 5 | TMT -131 |
Total Control | All Genotype | 72.90 ± 3.49 | 37.9% (18/29) | 62.1% (11/29) | 29 | -126, -127N, -127C, -128N, -128C |
Total AD | All Genotype | 85.24 ± 2.10 | 38.5% (10/26) | 61.5% (16/26) | 26 | -129N, -129C, -130N, -130C, -131 |