Table 5 List of Top 25 proteins significantly regulated in the cerebrovasculature of the inferior frontal gyrus in Alzheimer's disease vs controls from APOE4/4 genotypes
Gene ID | Label | Protein name | Biological function | log 2FC | P value |
|---|---|---|---|---|---|
RBM39 | Q14498 | RNA-binding protein 39 (CAPER alpha) (Hepatocellular carcinoma protein 1) | RNA binding | 0.594 | 0.000 |
Q59F66 | Q59F66 | DEAD box polypeptide 17 isoform p82 variant (Fragment) | Nucleic acid binding | 0.476 | 0.001 |
XRCC5 | P13010 | X-ray repair cross-complementing protein 5 | Damaged DNA binding | 0.752 | 0.001 |
PSD11 | O00231 | 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) | Structural molecule activity | 0.899 | 0.001 |
A0A024RAZ7 | A0A024RAZ7 | Heterogeneous nuclear ribonucleoprotein A1, isoform CRA_b | RNA binding | 0.694 | 0.001 |
DX39B | Q13838 | Spliceosome RNA helicase DDX39B | ATPase activity | 0.564 | 0.001 |
E7EMK3 | E7EMK3 | Flotillin-2 | Protease binding | − 0.731 | 0.001 |
B2R673 | B2R673 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex | Transferase activity, transferring acyl groups | − 0.605 | 0.001 |
SART3 | Q15020 | Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) | Histone binding | 0.571 | 0.001 |
ENOA | P06733 | Alpha-enolase | Cadherin binding | − 0.512 | 0.001 |
Q9HBB3 | Q9HBB3 | 60S ribosomal protein L6 | DNA binding | 0.227 | 0.002 |
PUF60 | Q9UHX1 | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) | Cadherin binding | 0.612 | 0.002 |
Q53SS8 | Q53SS8 | Epididymis secretory protein Li 85 (Poly(RC) binding protein 1) | DNA-binding transcription factor activity | 0.524 | 0.002 |
A0A0A6YYL6 | A0A0A6YYL6 | Protein RPL17-C18orf32 | Structural constituent of ribosome | 0.364 | 0.002 |
Q6ICQ8 | Q6ICQ8 | ARHG protein (Ras homolog gene family, member G (Rho G)) | GTPase activity | − 0.500 | 0.002 |
B5BU24 | B5BU24 | 14-3-3 protein beta/alpha | − 0.462 | 0.003 | |
SF3B2 | Q13435 | Splicing factor 3B subunit 2 | RNA binding | 0.435 | 0.003 |
A0A0C4DG89 | A0A0C4DG89 | Probable ATP-dependent RNA helicase DDX46 | ATP binding | 0.595 | 0.003 |
U520 | O75643 | U5 small nuclear ribonucleoprotein 200 kDa helicase | Helicase activity and ATP binding | 0.420 | 0.003 |
B2R7W4 | B2R7W4 | cDNA, FLJ93632, heterogeneous nuclear ribonucleoprotein R (HNRPR), mRNA | RNA binding | 0.675 | 0.003 |
A0A0S2Z4Z9 | A0A0S2Z4Z9 | Non-POU domain containing octamer-binding isoform 1 (Fragment) | RNA binding | 0.588 | 0.003 |
KPCB | P05771 | Protein kinase C beta type (PKC-B) (PKC-beta) | Calcium channel regulator activity | − 0.233 | 0.004 |
B5BUB1 | B5BUB1 | RuvB-like helicase (EC 3.6.4.12) (Fragment) | 5'-3' DNA helicase activity | 0.258 | 0.004 |
B5BUB5 | B5BUB5 | Autoantigen La (Fragment) | RNA binding | 1.177 | 0.004 |
PARP1 | P09874 | Poly [ADP-ribose] polymerase 1 (PARP-1) | DNA binding | 0.625 | 0.004 |