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Table 5 List of Top 25 proteins significantly regulated in the cerebrovasculature of the inferior frontal gyrus in Alzheimer's disease vs controls from APOE4/4 genotypes

From: APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains

Gene ID Label Protein name Biological function log 2FC P value
RBM39 Q14498 RNA-binding protein 39 (CAPER alpha) (Hepatocellular carcinoma protein 1) RNA binding 0.594 0.000
Q59F66 Q59F66 DEAD box polypeptide 17 isoform p82 variant (Fragment) Nucleic acid binding 0.476 0.001
XRCC5 P13010 X-ray repair cross-complementing protein 5 Damaged DNA binding 0.752 0.001
PSD11 O00231 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) Structural molecule activity 0.899 0.001
A0A024RAZ7 A0A024RAZ7 Heterogeneous nuclear ribonucleoprotein A1, isoform CRA_b RNA binding 0.694 0.001
DX39B Q13838 Spliceosome RNA helicase DDX39B ATPase activity 0.564 0.001
E7EMK3 E7EMK3 Flotillin-2 Protease binding − 0.731 0.001
B2R673 B2R673 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex Transferase activity, transferring acyl groups − 0.605 0.001
SART3 Q15020 Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) Histone binding 0.571 0.001
ENOA P06733 Alpha-enolase Cadherin binding − 0.512 0.001
Q9HBB3 Q9HBB3 60S ribosomal protein L6 DNA binding 0.227 0.002
PUF60 Q9UHX1 Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) Cadherin binding 0.612 0.002
Q53SS8 Q53SS8 Epididymis secretory protein Li 85 (Poly(RC) binding protein 1) DNA-binding transcription factor activity 0.524 0.002
A0A0A6YYL6 A0A0A6YYL6 Protein RPL17-C18orf32 Structural constituent of ribosome 0.364 0.002
Q6ICQ8 Q6ICQ8 ARHG protein (Ras homolog gene family, member G (Rho G)) GTPase activity − 0.500 0.002
B5BU24 B5BU24 14-3-3 protein beta/alpha   − 0.462 0.003
SF3B2 Q13435 Splicing factor 3B subunit 2 RNA binding 0.435 0.003
A0A0C4DG89 A0A0C4DG89 Probable ATP-dependent RNA helicase DDX46 ATP binding 0.595 0.003
U520 O75643 U5 small nuclear ribonucleoprotein 200 kDa helicase Helicase activity and ATP binding 0.420 0.003
B2R7W4 B2R7W4 cDNA, FLJ93632, heterogeneous nuclear ribonucleoprotein R (HNRPR), mRNA RNA binding 0.675 0.003
A0A0S2Z4Z9 A0A0S2Z4Z9 Non-POU domain containing octamer-binding isoform 1 (Fragment) RNA binding 0.588 0.003
KPCB P05771 Protein kinase C beta type (PKC-B) (PKC-beta) Calcium channel regulator activity − 0.233 0.004
B5BUB1 B5BUB1 RuvB-like helicase (EC 3.6.4.12) (Fragment) 5'-3' DNA helicase activity 0.258 0.004
B5BUB5 B5BUB5 Autoantigen La (Fragment) RNA binding 1.177 0.004
PARP1 P09874 Poly [ADP-ribose] polymerase 1 (PARP-1) DNA binding 0.625 0.004
  1. Tables show the biological functions of the top 25 significant proteins between AD vs controls cases from the APOE4/E4 genotype background