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Fig. 6 | Molecular Brain

Fig. 6

From: The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells

Fig. 6

Schematic diagram of Homer2a/2e and their possible role. A Schematic structure of Homer2a and 2e. Long Homer2a has EVH-1 domain in N-terminal and coiled-coil domain in C-terminal. Homer2e has only EVH-1 domain and lack of coiled-coil domain. B Schematic diagram of the possible role of Homer2a and 2e. Left: Long Homer2a multimerizes using their C-terminus coiled-coil domain and binds to Shank and Drebrin using their N-terminus EVH-1 domain to stabilize NMDAR at the postsynaptic site via GKAP, PSD95 and F-actin complex. Right: Ischemic condition induces Homer2e and it prevents the binding between Homer2a and Shank/Drebrin by takeover their EVH-1 binding sites, which enhances declustering of the protein complex including NMDAR in the postsynaptic site

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