Table 1 Demographic details of the post-mortem midbrain mRNA and protein cohorts classified by diagnosis. Table previously published in [17, 55]
From: Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Demographics | mRNA Cohort | Protein Cohort | ||||
|---|---|---|---|---|---|---|
Control (28) | SCZ (28) | Statistics | Control (28) | SCZ (26) | Statistics | |
Age (years) (range) | 50.54 (22–67) | 51.36 (26–67) | t(54) = − 0.27, p = 0.79 | 52.21 (22–69) | 52.29 (26—67) | t(52) = − 0.23, p = 0.82 |
Sex (M,F) | (20,8) | (19,9) | χ2(1,56) = 0.084, p = 0.771 | (19,9) | (16,10) | χ2(1,54) = 0.236, p = 0.627 |
pH | 6.66 ± 0.26 | 6.51 ± 0.20 | t(54) = 2.52, p = 0.015* | 6.69 ± 0.24 | 6.51 ± 0.23 | t(52) = 2.62, p = 0.011* |
PMI (hours) (range) | 31.68 ± 10.21 (15–50) | 35.66 ± 17.71 (5–72) | t(54) = − 1.03, p = 0.31 | 32.75 ± 9.90 (15–50) | 38.21 ± 18.20 (5–72) | t(52) = − 1.38, p = 0.17 |
RIN (range) | 5.56 ± 1.15 (3.0–7.3) | 5.61 ± 1.31 (3.2–8.3) | t(54) = − 0.15, p = 0.88 | – | – | – |
Duration of illness | – | 28.31 ± 12.72 (4–49) | – | – | 29.12 ± 13.02 (4–49) | – |
Daily CPZ (mg) | – | 736.45 ± 520.50 | – | – | 716.37 ± 557.76 | – |
Last recorded CPZ (mg) | – | 597.54 ± 497.64 | – | – | 616.20 ± 506.60 | – |
Lifetime CPZ (g) | – | 8231.44 ± 8714.24 | – | – | 8427.92 ± 9348.47 | – |