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Fig. 4 | Molecular Brain

Fig. 4

From: Reversibility of motor dysfunction in the rat model of NGLY1 deficiency

Fig. 4

Intracerebroventricular AAV9-hNGLY1 administration attenuated motor deficits in Ngly1−/− rats. a Experimental paradigm. Rats’ motor function was analyzed for eight weeks after virus injection. Circle; rota-rod test, square; gait analysis, triangle; grip-strength test. b Accelerating rota-rod testing for motor coordination of AAV-injected Ngly1−/− and WT rats at several ages. The time until falling from the accelerating rod (4–40 rpm for 4 min) is measured as the latency time to fall. c Representative paw placement records of 10-week-old AAV-injected rats. d Stride lengths of 10-week-old rats in the gait analysis 7 weeks after AAV-injection. Values represent mean ± S.E.M. The number of rats examined is shown in parentheses. *P < 0.05, **P < 0.01. n.s. = no significance

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