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Table 1 Influence of zinc supplementation on glutamatergic synaptic density

From: In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons

Synapse density per 10 µm of dendrite ± standard error of the mean, N = number of neurons

 

Control

With Zn2+ Supplementation

p-value

Zinc-induced change in synapse density

EGFP

5.04 ± 0.61, N = 26

7.05 ± 0.83, N = 15

0.041

Shank2-wildtype

7.49 ± 0.83, N = 26

7.34 ± 0.92, N = 24

0.83

Shank2-S557N

5.21 ± 0.61, N = 30

7.26 ± 0.69, N = 28

0.022

Shank2-V717F

5.17 ± 0.44, N = 30

6.99 ± 0.65, N = 24

0.018

Shank2-L1722P

4.26 ± 0.50, N = 28

11.70 ± 1.08, N = 15

 < 0.0001

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