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Table 1 Influence of zinc supplementation on glutamatergic synaptic density

From: In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons

Synapse density per 10 µm of dendrite ± standard error of the mean, N = number of neurons
  Control With Zn2+ Supplementation p-value Zinc-induced change in synapse density
EGFP 5.04 ± 0.61, N = 26 7.05 ± 0.83, N = 15 0.041
Shank2-wildtype 7.49 ± 0.83, N = 26 7.34 ± 0.92, N = 24 0.83
Shank2-S557N 5.21 ± 0.61, N = 30 7.26 ± 0.69, N = 28 0.022
Shank2-V717F 5.17 ± 0.44, N = 30 6.99 ± 0.65, N = 24 0.018
Shank2-L1722P 4.26 ± 0.50, N = 28 11.70 ± 1.08, N = 15  < 0.0001 ↑↑↑