Fig. 2

Hv1 is required for pain hypersensitivity after SNT. A, B WT and Hv1 KO animals exhibit similar acute pain phenotypes in a tail flick test (A) and motor learning capabilities in a rotarod test (B). Data are presented as mean ± SEM, n = 5—6 for each group. WT vs. Hv1 KO., unpaired t-test for tail flick, one-way ANOVA for rotarod. C, D Hv1 KO mice display reduced mechanical allodynia (C) and thermal hyperalgesia (D) following SNT. Data are presented as mean ± SEM, n = 14 mice for each group. **p < 0.01. WT ipsi vs. Hv1 KO ipsi., unpaired t-test. E, F Hv1 KO animals show reduced mechanical allodynia (E) and thermal hyperalgesia (F) following CPN ligation. Data are presented as mean ± SEM, n = 8 for WT, n = 7 for Hv1 KO. **p < 0.01; ***p < 0.001. WT ipsi vs. Hv1 KO ipsi., unpaired t-test