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Fig. 8 | Molecular Brain

Fig. 8

From: The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury

Fig. 8

Schematic diagram showing Hv1-dependent microglia-astrocyte interaction in neuropathic pain. After peripheral nerve injury, spinal microglia are activated and accompanied with Hv1 proton channel dependent ROS production. ROS acts on both neurons and astrocytes, triggering IFN-γ release. IFN-γ in turn contributes to further microglia activation and microglia-astrocyte interaction to maintain pain hypersensitivity after SNT

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