Fig. 1
Effects of ICaT in the model neuron on rebound depolarizations. For each isoform at the two temperatures the model was hyperpolarized (− 5 μA/cm2) for 70 ms and then depolarized to 3 μA/cm2 to assess the effects of a transient increase in ICaT on firing frequency. A–C Neuronal output (top traces) and corresponding inward ICaT current trajectories (lower traces) at the two temperatures for the three Cav3 isoforms. In the right panels (D–F) the firing frequencies are plotted as a function of the time since the end of the hyperpolarization for each of the three isoforms at both temperatures. Because these data were derived from mathematical modeling, no error bars are included